Article
Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b.
Gene - 1 Nov 2013
Matsuo Tomohito, Noguchi Yukiko, Shindo Mieko, Morita Yoshifumi, Oda Yoshie, Yoshida Eiko, Hamada Hiroko, Harada Mine, Shiokawa Yuichi, Nishida Takahiro, Tominaga Ryuji, Kikushige Yoshikane, Akashi Koichi, Kudoh Jun, Shimizu Nobuyoshi, Tanaka Yuka, Umemura Tsukuru, Taniguchi Taketoshi, Yoshimura Akihiko, Kobayashi Takashi, Mitsuyama Masao, Kurisaki Hironori, Katsuta Hitoshi, Nagafuchi Seiho
Abstract excerpt
Although mutations of autoimmune regulator (AIRE) gene are responsible for autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), presenting a wide spectrum of many characteristic and non-characteristic clinical features, some patients lack AIRE gene mutations. Therefore, something other than a mutation, such as dysregulation of AIRE gene, may be a causal factor for APECED or its related...
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