Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia.

British journal of haematology - 1 Oct 2013

Bean Christopher J, Boulet Sheree L, Yang Genyan, Payne Amanda B, Ghaji Nafisa, Pyle Meredith E, Hooper W Craig, Bhatnagar Pallav, Keefer Jeffrey, Barron-Casella Emily A, Casella James F, Debaun Michael R

Abstract excerpt

Genetic diversity at the human β-globin locus has been implicated as a modifier of sickle cell anaemia (SCA) severity. However, haplotypes defined by restriction fragment length polymorphism sites across the β-globin locus have not been consistently associated with clinical phenotypes. To define the genetic structure at the β-globin locus more thoroughly, we performed high-density single nucleotide polymorphism...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to beta-Globins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Child, Preschool

Share to Fetal Hemoglobin

Share to Haplotypes

Share to Linkage Disequilibrium

Share to Multigene Family

Source

Open in PubMed Open full text

Identifiers

PMID: 23952145
DOI: 10.1111/bjh.12507
PMCID: PMC4026174

Genes

HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acute chest syndrome is associated with single nucleotide polymorphism-defined beta globin cluster haplotype in children with sickle cell anaemia.PMID 23952145Read ↗

Identification of genetic variants associated with clinical features of sickle cell disease.Semantic proximity Read ↗

Genomic polymorphisms in sickle cell disease: implications for clinical diversity and treatment.Semantic proximity Read ↗

A polygenic score for acute vaso-occlusive pain in pediatric sickle cell disease.Semantic proximity Read ↗

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease.Semantic proximity Read ↗

A genetic risk score based on BCL11A and HBS1L-MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients.Semantic proximity Read ↗

Gene-centric association study of acute chest syndrome and painful crisis in sickle cell disease patients.Semantic proximity Read ↗

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.Semantic proximity Read ↗

High-density SNP genotyping to define beta-globin locus haplotypes.Semantic proximity Read ↗

Variation and impact of polygenic hematological traits in monogenic sickle cell diseaseSemantic proximity Read ↗

A phased SNP-based classification of sickle cell anemia HBB haplotypes.Semantic proximity Read ↗

Variation and impact of polygenic hematologic traits in monogenic sickle cell disease.Semantic proximity Read ↗

Genetic modulation of anemia severity, hemolysis level, and hospitalization rate in Angolan children with Sickle Cell Anemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.