Disorders from perturbations of nuclear-mitochondrial intergenomic cross-talk.

Abstract excerpt

In the course of evolution, mitochondria lost their independence, and mitochondrial DNA (mtDNA) became the 'slave' of nuclear DNA, depending on numerous nucleus-encoded factors for its integrity, replication and expression. Mutations in any of these factors may alter the cross-talk between the two genomes and cause Mendelian disorders characterized by qualitative (multiple deletions) or quantitative (depletion)...

Topics

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• DNA, Mitochondrial
• Disease Models, Animal
• Gene Deletion
• Mice
• Mitochondrial Diseases
• Mutation