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Article

Specific inhibition of tumor cells by oncogenic EGFR specific silencing by RNA interference.

PloS one - 1 Jan 2013

Takahashi Masaki, Chiyo Tomoko, Okada Takashi, Hohjoh Hirohiko

Abstract excerpt

Anticancer agents that have minimal effects on normal cells and tissues are ideal cancer drugs. Here, we show specific inhibition of human cancer cells carrying oncogenic mutations in the epidermal growth factor receptor (EGFR) gene by means of oncogenic allele-specific RNA interference (RNAi), both in vivo and in vitro. The allele-specific RNAi (ASP-RNAi) treatment did not affect normal cells or tissues that had...

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Source

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Identifiers

PMID: 23951344
DOI: 10.1371/journal.pone.0073214
PMCID: PMC3738543

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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