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Article

Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction.

PloS one - 1 Jan 2021

Ito Reina E, Oneyama Chitose, Aoki Kazuhiro

Abstract excerpt

Oncogene addiction is a cellular property by which cancer cells become highly dependent on the expression of oncogenes for their survival. Oncogene addiction can be exploited to design molecularly targeted drugs that kill only cancer cells by inhibiting the specific oncogenes. Genes and cell lines exhibiting oncogene addiction, as well as the mechanisms by which cell death is induced when addicted oncogenes are...

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Identifiers

PMID: 33793658
DOI: 10.1371/journal.pone.0249388
PMCID: PMC8016361

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