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Article

Improvement of a predictive model of castration-resistant prostate cancer: functional genetic variants in TGFβ1 signaling pathway modulation.

PloS one - 1 Jan 2013

Teixeira Ana L, Gomes Mónica, Nogueira Augusto, Azevedo Andreia S, Assis Joana, Dias Francisca, Santos Juliana I, Lobo Francisco, Morais António, Maurício Joaquina, Medeiros Rui

Abstract excerpt

Prostate cancer (PC) is the most frequently diagnosed cancer in men. The acquisition of castration-resistant (CR) phenotype is associated with the activation of signaling pathways mediated by growth factors. The TGFβ1 and its receptors have an important role in tumor progression, being the pro-apoptotic function modulated by the expression of TGFBR2. A single nucleotide polymorphism -875 G > A in TGFBR2 gene has...

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Source

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Identifiers

PMID: 23951322
DOI: 10.1371/journal.pone.0072419
PMCID: PMC3739770

Genes

TGFBR2
SMAD7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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