Article
Transforming growth factor-beta 1 gene polymorphisms and expression in the blood of prostate cancer patients.
Cancer investigation - 1 Dec 2007
Faria Paula Cristina, Saba Karla, Neves Adriana Freitas, Cordeiro Elisangela Rosa, Marangoni Karina, Freitas Danielo Garcia, Goulart Luiz Ricardo
Abstract excerpt
The transforming growth factor beta 1 (TGF-beta1) is a multifunctional cytokine with several regulatory activities in tumor cells affecting growth, differentiation, and function. Alterations in gene expression, secretion, and regulation of TGF-beta1 may lead to a favorable environment for tumor development by angiogenesis stimulation and immune system suppression. We evaluated the influence of the TGFB1...
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