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Article

Functional polymorphisms in FAS/FASL system increase the risk of neuroblastoma in Chinese population.

PloS one - 1 Jan 2013

Han Wei, Zhou Yuling, Zhong Rong, Wu Chen, Song Ranran, Liu Li, Zou Li, Qiao Yan, Zhai Kan, Chang Jiang, Huang Liming, Liu Li, Lu Xuzai, Lou Jiao, Yu Dianke, Tan Wen, Zhang Jinzhe, Wang Huanmin, Miao Xiaoping

Abstract excerpt

The FAS and FASL system plays a substantial role in apoptosis and immune escape of cells. Three polymorphisms located in the promoter regions of FAS (-1377G/A and -670A/G) and FASL (-844T/C) have been shown to alter the transcriptional activity of the genes, respectively. This study was conducted to evaluate the effects of these polymorphisms on the susceptibility of neuroblastoma in the Chinese population. A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23951214
DOI: 10.1371/journal.pone.0071656
PMCID: PMC3741122

Genes

FAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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