Article
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
PLoS genetics - 21 Oct 2010
Jurado Sabine, Smyth Ian, van Denderen Bryce, Tenis Nora, Hammet Andrew, Hewitt Kimberly, Ng Jane-Lee, McNees Carolyn J, Kozlov Sergei V, Oka Hayato, Kobayashi Masahiko, Conlan Lindus A, Cole Timothy J, Yamamoto Ken-Ichi, Taniguchi Yoshihito, Takeda Shunichi, Lavin Martin F, Heierhorst Jörg
Abstract excerpt
Zn²(+)-finger proteins comprise one of the largest protein superfamilies with diverse biological functions. The ATM substrate Chk2-interacting Zn²(+)-finger protein (ASCIZ; also known as ATMIN and ZNF822) was originally linked to functions in the DNA base damage response and has also been proposed to be an essential cofactor of the ATM kinase. Here we show that absence of ASCIZ leads to p53-independent...
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