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Article

acr-23 Encodes a monepantel-sensitive channel in Caenorhabditis elegans.

PLoS pathogens - 1 Jan 2013

Rufener Lucien, Bedoni Nicola, Baur Roland, Rey Samantha, Glauser Dominique A, Bouvier Jacques, Beech Robin, Sigel Erwin, Puoti Alessandro

Abstract excerpt

Monepantel is a member of the recently identified class of anthelmintics known as the amino-acetonitrile derivatives (AADs). Monepantel controls all major gastro-intestinal nematodes in sheep including those that are resistant to the classical anthelmintics. Previous studies have shown that the Caenorhabditis elegans acr-23 and the Haemonchus contortus Hco-mptl-1 genes may be prominent targets of monepantel. With...

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Identifiers

PMID: 23950710
DOI: 10.1371/journal.ppat.1003524
PMCID: PMC3738477

Genes

ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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