Article

A Cationic Amphiphilic Drug (CAD) Defense System in the Nematode <i>Caenorhabditis elegans</i>

2026-01-03

Abstract excerpt

Cationic Amphiphilic Drugs (CADs) severely disrupt lysosomal function, which leads to a cellular pathology characterized by excess phospholipids called phospholipidosis. Through a forward genetic screen and mining of published datasets, we discovered that CADs induce the expression of the CYP-35B family of cytochrome P450s and the PGP-13 p-glycoprotein pump via the nuclear receptors NHR-70 and NHR-107 in the nemat...

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Literature Corpus work: fa3268ac-c75b-54ab-b55c-aa73e30d6433
DOI: 10.64898/2026.01.03.697488

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