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Article

How well does a funneled energy landscape capture the folding mechanism of spectrin domains?

The journal of physical chemistry. B - 24 Oct 2013

Best Robert B

Abstract excerpt

Three structurally similar domains from α-spectrin have been shown to fold very differently. First, there is a contrast in the folding mechanism, as probed by Φ-value analysis, between the R15 domain and the R16 and R17 domains. Second, there are very different contributions from internal friction to folding: the folding rate of the R15 domain was found to be inversely proportional to solvent viscosity, showing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23947368
DOI: 10.1021/jp403305a
PMCID: PMC3808457

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