Article
Separating the effects of internal friction and transition state energy to explain the slow, frustrated folding of spectrin domains.
Proceedings of the National Academy of Sciences of the United States of America - 30 Oct 2012
Wensley Beth G, Kwa Lee Gyan, Shammas Sarah L, Rogers Joseph M, Browning Stuart, Yang Ziqi, Clarke Jane
Abstract excerpt
The elongated three-helix bundle domains spectrin R16 and R17 fold some two to three orders of magnitude more slowly than their homologue R15. We have shown that this slow folding is due, at least in part, to roughness in the free-energy landscape of R16 and R17. We have proposed that this roughness is due to a frustrated search for the correct docking of partly preformed helices. However, this accounts for only...
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