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Article

Different members of a simple three-helix bundle protein family have very different folding rate constants and fold by different mechanisms.

Journal of molecular biology - 31 Jul 2009

Wensley Beth G, Gärtner Martina, Choo Wan Xian, Batey Sarah, Clarke Jane

Abstract excerpt

The 15th, 16th, and 17th repeats of chicken brain alpha-spectrin (R15, R16, and R17, respectively) are very similar in terms of structure and stability. However, R15 folds and unfolds 3 orders of magnitude faster than R16 and R17. This is unexpected. The rate-limiting transition state for R15 folding is investigated using protein engineering methods (Phi-value analysis) and compared with previously completed...

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Identifiers

PMID: 19445951
DOI: 10.1016/j.jmb.2009.05.010
PMCID: PMC2852649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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