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Article

Friction-Limited Folding of Disulfide-Reduced Monomeric SOD1.

Biophysical journal - 21 Apr 2020

Cohen Noah R, Kayatekin Can, Zitzewitz Jill A, Bilsel Osman, Matthews C R

Abstract excerpt

The folding reaction of a stable monomeric variant of Cu/Zn superoxide dismutase (mSOD1), an enzyme responsible for the conversion of superoxide free radicals into hydrogen peroxide and oxygen, is known to be among the slowest folding processes that adhere to two-state behavior. The long lifetime, ∼10 s, of the unfolded state presents ample opportunities for the polypeptide chain to transiently sample nonnative...

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Identifiers

PMID: 32191862
DOI: 10.1016/j.bpj.2020.02.028
PMCID: PMC7175461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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