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Article

Cryptococcus neoformans ex vivo capsule size is associated with intracranial pressure and host immune response in HIV-associated cryptococcal meningitis.

The Journal of infectious diseases - 1 Jan 2014

Robertson Emma J, Najjuka Grace, Rolfes Melissa A, Akampurira Andrew, Jain Neena, Anantharanjit Janani, von Hohenberg Maximilian, Tassieri Manlio, Carlsson Allan, Meya David B, Harrison Thomas S, Fries Bettina C, Boulware David R, Bicanic Tihana

Abstract excerpt

BACKGROUND: The Cryptococcus neoformans polysaccharide capsule is a well-characterized virulence factor with immunomodulatory properties. The organism and/or shed capsule is postulated to raise intracranial pressure (ICP) in cryptococcal meningitis (CM) by mechanical obstruction of cerebrospinal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23945372
DOI: 10.1093/infdis/jit435
PMCID: PMC3864387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23945372-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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