Article
Mitochondrial haplogroups modify the risk of developing hypertrophic cardiomyopathy in a Danish population.
PloS one - 1 Jan 2013
Hagen Christian M, Aidt Frederik H, Hedley Paula L, Jensen Morten K, Havndrup Ole, Kanters Jørgen K, Moolman-Smook Johanna C, Larsen Severin O, Bundgaard Henning, Christiansen Michael
Abstract excerpt
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in genes coding for proteins involved in sarcomere function. The disease is associated with mitochondrial dysfunction. Evolutionarily developed variation in mitochondrial DNA (mtDNA), defining mtDNA haplogroups and haplogroup clusters, is associated with functional differences in mitochondrial function and susceptibility to various...
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