Article
Evolutionary dissection of mtDNA hg H: a susceptibility factor for hypertrophic cardiomyopathy.
Mitochondrial DNA. Part A, DNA mapping, sequencing, and analysis - 1 Aug 2020
Hagen Christian M, Elson Joanna L, Hedley Paula L, Aidt Frederik H, Havndrup Ole, Jensen Morten K, Kanters Jørgen K, Atherton John J, McGaughran Julie, Bundgaard Henning, Christiansen Michael
Abstract excerpt
Mitochondrial DNA (mtDNA) haplogroup (hg) H has been reported as a susceptibility factor for hypertrophic cardiomyopathy (HCM). This was established in genetic association studies, however, the SNP or SNP's that are associated with the increased risk have not been identified. Hg H is the most frequent European mtDNA hg with greater than 80 subhaplogroups (subhgs) each defined by specific SNPs. We tested the...
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