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Article

Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants.

Proceedings of the National Academy of Sciences of the United States of America - 27 Aug 2013

Geisler Katrin, Hughes Richard K, Sainsbury Frank, Lomonossoff George P, Rejzek Martin, Fairhurst Shirley, Olsen Carl-Erik, Motawia Mohammed Saddik, Melton Rachel E, Hemmings Andrew M, Bak Søren, Osbourn Anne

Abstract excerpt

Members of the cytochromes P450 superfamily (P450s) catalyze a huge variety of oxidation reactions in microbes and higher organisms. Most P450 families are highly divergent, but in contrast the cytochrome P450 14α-sterol demethylase (CYP51) family is one of the most ancient and conserved, catalyzing sterol 14α-demethylase reactions required for essential sterol synthesis across the fungal, animal, and plant...

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PMID: 23940321
DOI: 10.1073/pnas.1309157110
PMCID: PMC3761579

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Biochemical analysis of a multifunctional cytochrome P450 (CYP51) enzyme required for synthesis of antimicrobial triterpenes in plants.PMID 23940321Read ↗

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