Article
Mutation of the CgPDR16 gene attenuates azole tolerance and biofilm production in pathogenic Candida glabrata.
Yeast (Chichester, England) - 1 Oct 2013
Culakova Hana, Dzugasova Vladimira, Perzelova Jana, Gbelska Yvetta, Subik Julius
Abstract excerpt
The PDR16 gene encodes the homologue of Sec14p, participating in protein secretion, regulation of lipid synthesis and turnover in vivo and acting as a phosphatidylinositol transfer protein in vitro. This gene is also involved in the regulation of multidrug resistance in Saccharomyces cerevisiae and pathogenic yeasts. Here we report the results of functional analysis of the CgPDR16 gene, whose mutation has been...
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