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Article

Let-7 Sensitizes KRAS Mutant Tumor Cells to Chemotherapy.

PloS one - 1 Jan 2015

Dai Xin, Jiang Ying, Tan Chalet

Abstract excerpt

KRAS is the most commonly mutated oncogene in human cancers and is associated with poor prognosis and drug resistance. Let-7 is a family of tumor suppressor microRNAs that are frequently suppressed in solid tumors, where KRAS mutations are highly prevalent. In this study, we investigated the potential use of let-7 as a chemosensitizer. We found that let-7b repletion selectively sensitized KRAS mutant tumor cells...

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Identifiers

PMID: 25946136
DOI: 10.1371/journal.pone.0126653
PMCID: PMC4422443

Genes

KRAS

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