Article
Profiling the cross reactivity of ubiquitin with the Nedd8 activating enzyme by phage display.
PloS one - 1 Jan 2013
Zhao Bo, Zhang Keya, Bhuripanyo Karan, Choi Chan Hee J, Villhauer Eric B, Li Heng, Zheng Ning, Kiyokawa Hiroaki, Schindelin Hermann, Yin Jun
Abstract excerpt
The C-terminal peptides of ubiquitin (UB) and UB-like proteins (UBLs) play a key role in their recognition by the specific activating enzymes (E1s) to launch their transfer through the respective enzymatic cascades thus modifying cellular proteins. UB and Nedd8, a UBL regulating the activity of c...
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