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Article

Competence-independent activity of pneumococcal EndA [corrected] mediates degradation of extracellular dna and nets and is important for virulence.

PloS one - 1 Jan 2013

Zhu Luchang, Kuang Zhizhou, Wilson Brenda A, Lau Gee W

Abstract excerpt

Membrane surface localized endonuclease EndA of the pulmonary pathogen Streptococcus pneumoniae (pneumococcus) is required for both genetic transformation and virulence. Pneumococcus expresses EndA during growth. However, it has been reported that EndA has no access to external DNA when pneumococcal cells are not competent for genetic transformation, and thus, unable to degrade extracellular DNA. Here, by using...

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Identifiers

PMID: 23936195
DOI: 10.1371/journal.pone.0070363
PMCID: PMC3729463

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Source receipt: pubmed, retrieved 7 Sept 2026.

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