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Article

Genetic and structural characterization of endA. A membrane-bound nuclease required for transformation of Streptococcus pneumoniae.

Journal of molecular biology - 20 Jun 1990

Puyet A, Greenberg B, Lacks S A

Abstract excerpt

The endA gene encoding the membrane nuclease of Streptococcus pneumoniae, which is necessary for DNA uptake in genetic transformation, was cloned in a streptococcal vector. This was accomplished by insertional mutagenesis of the gene, cloning of the mutant allele, and substitution of the wild-type allele by chromosomal facilitation of plasmid establishment. Plasmids carrying the endA+ gene complemented cells with...

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Identifiers

PMID: 2359120
DOI: 10.1016/S0022-2836(05)80259-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic and structural characterization of endA. A membrane-bound nuclease required for transformation of Streptococcus pneumoniae.PMID 2359120Read ↗

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