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The Pneumococcal Cell Wall Degrading Enzymes: A Modular Design to Create New Lysins?

1 Jun 1997

Abstract excerpt

Autolysins are enzymes that degrade different bonds in the peptidoglycan and, eventually, cause the lysis and death of the cell. Streptococcus pneumoniae contains a powerful autolytic enzyme that has been characterized as an N-acetylmuramoyl-L-alanine amidase. We have cloned the lytA gene coding for this amidase and studied in depth the genetics and expression of this gene, which represented the first molecular...

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Identifiers

PMID: 9185148
DOI: 10.1089/mdr.1997.3.199

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