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Article

Dynamic capsule restructuring by the main pneumococcal autolysin LytA in response to the epithelium.

Nature communications - 29 Feb 2016

Kietzman Colin C, Gao Geli, Mann Beth, Myers Lance, Tuomanen Elaine I

Abstract excerpt

Bacterial pathogens produce complex carbohydrate capsules to protect against bactericidal immune molecules. Paradoxically, the pneumococcal capsule sensitizes the bacterium to antimicrobial peptides found on epithelial surfaces. Here we show that upon interaction with antimicrobial peptides, encapsulated pneumococci survive by removing capsule from the cell surface within minutes in a process dependent on the...

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Share to Bacterial Adhesion
Share to Bacterial Capsules
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to N-Acetylmuramoyl-L-alanine Amidase

Share to Pneumococcal Infections

Share to Pneumonia, Pneumococcal

Share to Streptococcus pneumoniae

Source

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Identifiers

PMID: 26924467
DOI: 10.1038/ncomms10859
PMCID: PMC4773454

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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