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Competence remodels the pneumococcal cell wall exposing key surface virulence factors that mediate increased host adherence

30 Jan 2023

Abstract excerpt

Competence development in the human pathogen Streptococcus pneumoniae controls several features such as genetic transformation, biofilm formation, and virulence. Competent bacteria produce so-called "fratricins" such as CbpD that kill noncompetent siblings by cleaving peptidoglycan (PGN). CbpD is a choline-binding protein (CBP) that binds to phosphorylcholine residues found on wall and lipoteichoic acids (WTA and...

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PMID: 36716340
DOI: 10.1371/journal.pbio.3001990

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