Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population.

doi:10.1038/pcan.2015.63

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Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population.

Prostate cancer and prostatic diseases - 1 Mar 2016

Henríquez-Hernández L A, Valenciano A, Foro-Arnalot P, Álvarez-Cubero M J, Cozar J M, Suárez-Novo J F, Castells-Esteve M, Fernández-Gonzalo P, De-Paula-Carranza B, Ferrer M, Guedea F, Sancho-Pardo G, Craven-Bartle J, Ortiz-Gordillo M J, Cabrera-Roldán P, Rodríguez-Melcón J I, Herrera-Ramos E, Rodríguez-Gallego C, Lara P C

Abstract excerpt

BACKGROUND: Novel predictors of prognosis and treatment response for prostate cancer (PCa) are required to better individualize treatment. Single-nucleotide polymorphisms (SNPs) in four genes directly (XRCC5 (X-ray repair complementing defective repair in Chinese hamster cells 5) and XRCC6 (X-ray repair complementing defective repair in Chinese hamster cells 6)) or indirectly (PARP1 and major vault protein (MVP))...

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Identifiers

PMID: 26754263
DOI: 10.1038/pcan.2015.63

Genes

MVP
XRCC6
PARP1
XRCC5

Provenance

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