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Article

Genotype directed therapy in murine mismatch repair deficient tumors.

PloS one - 1 Jan 2013

Kucherlapati Melanie H, Esfahani Shadi, Habibollahi Peiman, Wang Junning, Still Eric R, Bronson Roderick T, Mahmood Umar, Kucherlapati Raju S

Abstract excerpt

The PI3K/AKT/mTOR pathway has frequently been found activated in human tumors. We show that in addition to Wnt signaling dysfunction, the PI3K/AKT/mTOR pathway is often upregulated in mouse Msh2(-/-) initiated intestinal tumors. NVP-BEZ235 is a dual PI3K/mTOR inhibitor toxic to many cancer cell lines and currently involved in clinical trials. We have treated two mouse models involving Msh2 that develop small...

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Identifiers

PMID: 23935891
DOI: 10.1371/journal.pone.0068817
PMCID: PMC3720855

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PDPK1
PTEN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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