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Article

Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels.

Aging - 3 Dec 2020

Huang Tianwen, Fang Lijun, He Raoli, Weng Huidan, Chen Xiaochun, Ye Qinyong, Qu Dianbo

Abstract excerpt

Pink1, Parkin and Fbxo7, three autosomal recessive familial genes of Parkinson's disease (PD), have been implicated in mitophagy pathways for quality control and clearance of damaged mitochondria, but the interplay of these three genes still remains unclear. Here we present that Fbxo7 and Pink1 play a reciprocal role in the regulation of their protein levels. Regardless of the genotypes of Fbxo7, the wild type...

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Identifiers

PMID: 33291077
DOI: 10.18632/aging.202236
PMCID: PMC7835017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Fbxo7 and Pink1 play a reciprocal role in regulating their protein levels.PMID 33291077Read ↗

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Structural Mechanisms of Mitochondrial Quality Control Mediated by PINK1 and ParkinSemantic proximity Read ↗

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FBXO7/ntc and USP30 antagonistically set the ubiquitination threshold for basal mitophagy and provides a target for Pink1 phosphorylation <i>in vivo</i>Semantic proximity Read ↗

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