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Article

Modeling and estimation of kinetic parameters and replicative fitness of HIV-1 from flow-cytometry-based growth competition experiments.

Bulletin of mathematical biology - 1 Aug 2008

Miao Hongyu, Dykes Carrie, Demeter Lisa M, Cavenaugh James, Park Sung Yong, Perelson Alan S, Wu Hulin

Abstract excerpt

Growth competition assays have been developed to quantify the relative fitness of HIV-1 mutants. In this article, we develop mathematical models to describe viral/cellular dynamic interactions in the assay system from which the competitive fitness indices or parameters are defined. In our previous HIV-viral fitness experiments, the concentration of uninfected target cells was assumed to be constant (Wu et al....

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Identifiers

PMID: 18648886
DOI: 10.1007/s11538-008-9323-4
PMCID: PMC4065495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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