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Article

Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis.

Neuron - 7 Aug 2013

Ling Shuo-Chien, Polymenidou Magdalini, Cleveland Don W

Abstract excerpt

Breakthrough discoveries identifying common genetic causes for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these disorders. They share unexpectedly similar signatures, including dysregulation in common molecular players including TDP-43, FUS/TLS, ubiquilin-2, VCP, and expanded hexanucleotide repeats within the C9ORF72 gene. Dysfunction in RNA processing and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23931993
DOI: 10.1016/j.neuron.2013.07.033
PMCID: PMC4411085

Genes

FUS
VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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