Article
5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jan 2014
Lennertz Leonhard, Wagner Michael, Grabe Hans Jörgen, Franke Petra E, Guttenthaler Vera, Rampacher Friederike, Schulze-Rauschenbach Svenja, Vogeley Andrea, Benninghoff Jens, Ruhrmann Stephan, Pukrop Ralf, Klosterkötter Joachim, Falkai Peter, Maier Wolfgang, Mössner Rainald
Abstract excerpt
A role of the HTR3A-E genes in obsessive-compulsive disorder (OCD) can be expected based on promising effects of 5-HT3 receptor antagonists as adjunctive treatment of OCD. We therefore genotyped six common coding or promoter variants within the HTR3A-E genes in a case-control-sample consisting of N=236 OCD patients and N=310 control subjects and in N=58 parent-child-trios. Given the heterogeneous OCD phenotype,...
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