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Article

RET/PTC rearrangements and BRAF mutations in thyroid tumorigenesis.

Endocrinology - 1 Mar 2007

Ciampi Raffaele, Nikiforov Yuri E

Abstract excerpt

Thyroid papillary carcinoma is the most common type of endocrine cancer. It is frequently associated with genetic alterations leading to activation of the MAPK signaling pathway. The two most frequently affected genes, BRAF and RET, are activated by either point mutation or as a result of chromosomal rearrangement. These mutations are tumorigenic in thyroid follicular cells and correlate with specific...

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Share to Carcinoma, Papillary
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16946010
DOI: 10.1210/en.2006-0921

Genes

BRAF
RET

Provenance

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