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Article

BRAFV600E Overrides NOTCH Signaling in Thyroid Cancer.

Thyroid : official journal of the American Thyroid Association - 1 May 2021

Traversi Florian, Stooss Amandine, Dettmer Matthias S, Charles Roch-Philippe

Abstract excerpt

Background: Several mechanisms likely cooperate with the mitogen-activated protein (MAP)-kinase pathway to promote cancer progression in the thyroid. One putative pathway is NOTCH signaling, which is implicated in several other malignancies. In thyroid cancer, data regarding the role of the NOTCH pathway are insufficient and even contradictory. Methods: A BRAFV600E-driven papillary thyroid carcinoma (PTC) mouse...

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PMID: 33012268
DOI: 10.1089/thy.2019.0595

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