The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.

doi:10.1136/annrheumdis-2013-203772

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Article

The effect of FTO variation on increased osteoarthritis risk is mediated through body mass index: a Mendelian randomisation study.

Annals of the rheumatic diseases - 1 Dec 2014

Panoutsopoulou Kalliope, Metrustry Sarah, Doherty Sally A, Laslett Laura L, Maciewicz Rose A, Hart Deborah J, Zhang Weiya, Muir Kenneth R, Wheeler Margaret, Cooper Cyrus, Spector Tim D, Cicuttini Flavia M, Jones Graeme, Arden Nigel K, Doherty Michael, Zeggini Eleftheria, Valdes Ana M

Abstract excerpt

OBJECTIVE: Variation in the fat mass and obesity-associated (FTO) gene influences susceptibility to obesity. A variant in the FTO gene has been implicated in genetic risk to osteoarthritis (OA). We examined the role of the FTO polymorphism rs8044769 in risk of knee and hip OA in cases and controls incorporating body mass index (BMI) information. METHODS: 5409 knee OA patients, 4355 hip OA patients and up to 5362...

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PMID: 23921993
DOI: 10.1136/annrheumdis-2013-203772
PMCID: PMC4251538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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