FTO variant is not associated with osteoarthritis in the Chinese Han population: replication study for a genome-wide association study identified risk loci.

doi:10.1186/s13018-018-0769-2

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Article

FTO variant is not associated with osteoarthritis in the Chinese Han population: replication study for a genome-wide association study identified risk loci.

Journal of orthopaedic surgery and research - 2 Apr 2018

Dai Jin, Ying Pu, Shi Dongquan, Hou Huacheng, Sun Ye, Xu Zhihong, Chen Dongyang, Zhang Guoqiang, Ni Ming, Teng Huajian, Wang Yan, Jiang Qing

Abstract excerpt

BACKGROUND: Osteoarthritis is the most prevalent form of arthritis worldwide and is the major cause of pain and loss of function in elderly people. A signal of the fat mass and obesity-associated (FTO) gene had been reported in a genome-wide association study of osteoarthritis. The FTO polymorphism (rs8044769) might exert its effect on osteoarthritis through obesity, because it was reported as a body mass...

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PMID: 29606151
DOI: 10.1186/s13018-018-0769-2
PMCID: PMC5879643

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