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Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia

9 Jun 2013

Abstract excerpt

Acute lymphoblastic leukemia (ALL) is the commonest childhood malignancy and is characterized by recurring structural genetic alterations. Previous studies of DNA methylation suggest epigenetic alterations may also be important, but an integrated genome-wide analysis of genetic and epigenetic alterations in ALL has not been performed. We analyzed 137 B-lineage and 30 T-lineage childhood ALL cases using microarray...

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Share to Acute Lymphoblastic Leukemia research
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PMID: 23921123
DOI: 10.1172/jci66203

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