Article
Aberrantly expressed Bruton's tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells.
Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2020
Pikatan Narpati Wesa, Liu Yen-Lin, Bamodu Oluwaseun Adebayo, Hsiao Michael, Hsu Wen-Ming, Haryana Sofia Mubarika, Sutaryo, Chao Tsu-Yi, Yeh Chi-Tai
Abstract excerpt
PURPOSE: Neuroblastoma, a common childhood tumor, remains one of the most elusive diseases to treat. To date, high-risk neuroblastoma is associated with low survival rates. To address this, novel and more effective therapeutic strategies must continue to be explored. METHODS: We employed a bioinformatics approach corroborated with in vitro and in vivo data. Samples from neuroblastoma patients were retrieved and...
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