Article
Significance of Individual Domains of ClpL: A Novel Chaperone from Streptococcus mutans.
Biochemistry - 15 Sept 2020
Jana Biswanath, Biswas Indranil
Abstract excerpt
ClpL is a member of the HSP100 family of AAA+ chaperones that is widely present in Gram-positive but surprisingly absent in Gram-negative bacteria. ClpL is involved in various cellular processes, including stress tolerance response, long-term survival, virulence, and antibiotic resistance. ClpL is poorly characterized, and its molecular mechanisms of chaperone activity are largely unclear. Here, we biochemically...
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