Elucidating the pleiotropic effects of clpC deletion in Clostridioides difficile: proteomic and phenotypic insights.

Abstract excerpt

Clostridioides difficile is a major cause of antibiotic-associated diarrhea and a significant public health threat. During its infectious cycle, C. difficile encounters various stresses within the gastrointestinal tract. Clp proteases play a crucial role in bacterial stress responses and protein homeostasis. In this study, we investigated the role of the Clp ATPase, ClpC, in C. difficile physiology using genetic,...

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• Cell Wall
• Clostridioides difficile
• Endopeptidase Clp
• Heat-Shock Response
• Peptidoglycan