Article
A novel PITX2c loss‑of‑function mutation underlies lone atrial fibrillation.
International journal of molecular medicine - 1 Oct 2013
Zhou Yi-Meng, Zheng Peng-Xiang, Yang Yi-Qing, Ge Zhi-Ming, Kang Wei-Qiang
Abstract excerpt
Atrial fibrillation (AF) is the most common form of sustained cardiac arrhythmia responsible for substantial morbidity and significantly increased mortality rates. A growing body of evidence documents the important role of genetic defects in the pathogenesis of AF. However, AF is a heterogeneous disease and the genetic determinants for AF in an overwhelming majority of patients remain unknown. In the present...
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