Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours.

doi:10.1016/j.jtbi.2013.07.019

Article

Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours.

Journal of theoretical biology - 7 Nov 2013

Bonello Nicolas, Sampson James, Burn John, Wilson Ian J, McGrown Gail, Margison Geoff P, Thorncroft Mary, Crossbie Philip, Povey Andrew C, Santibanez-Koref Mauro, Walters Kevin

Abstract excerpt

We exploit model-based Bayesian inference methodologies to analyse lung tumour-derived methylation data from a CpG island in the O6-methylguanine-DNA methyltransferase (MGMT) promoter. Interest is in modelling the changes in methylation patterns in a CpG island in the first exon of the promoter d...

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Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours.

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