Article
Increased co-expression of genes harboring the damaging de novo mutations in Chinese schizophrenic patients during prenatal development.
Scientific reports - 15 Dec 2015
Wang Qiang, Li Miaoxin, Yang Zhenxing, Hu Xun, Wu Hei-Man, Ni Peiyan, Ren Hongyan, Deng Wei, Li Mingli, Ma Xiaohong, Guo Wanjun, Zhao Liansheng, Wang Yingcheng, Xiang Bo, Lei Wei, Sham Pak C, Li Tao
Abstract excerpt
Schizophrenia is a heritable, heterogeneous common psychiatric disorder. In this study, we evaluated the hypothesis that de novo variants (DNVs) contribute to the pathogenesis of schizophrenia. We performed exome sequencing in Chinese patients (N = 45) with schizophrenia and their unaffected parents (N = 90). Forty genes were found to contain DNVs. These genes had enriched transcriptional co-expression profile in...
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