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Article

Emergence of new pandemic GII.4 Sydney norovirus strain correlates with escape from herd immunity.

The Journal of infectious diseases - 1 Dec 2013

Debbink Kari, Lindesmith Lisa C, Donaldson Eric F, Costantini Veronica, Beltramello Martina, Corti Davide, Swanstrom Jesica, Lanzavecchia Antonio, Vinjé Jan, Baric Ralph S

Abstract excerpt

BACKGROUND: GII.4 noroviruses are a significant source of acute gastroenteritis worldwide, causing the majority of human norovirus outbreaks. Evolution of the GII.4 major capsid protein occurs rapidly, resulting in the emergence of new strains that produce successive waves of pandemic disease. A new pandemic isolate, GII.4 2012 Sydney, largely replaced previously circulating strains in late 2012. We compare the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23908476
DOI: 10.1093/infdis/jit370
PMCID: PMC3814837

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