Article
Preliminary crystallographic analysis of neuraminidase N2 from a new influenza A virus.
Acta crystallographica. Section F, Structural biology and crystallization communications - 1 Aug 2013
Gao Feng, Bao Jinku
Abstract excerpt
Influenza virus is a major viral respiratory pathogen that causes yearly epidemics in temperate climates. The H3N2 subtype is one of the major causative agents of severe epidemics and plays a critical role in vaccine development. The neuraminidase (NA) inhibitors oseltamivir and zanamivir are two commercially available NA-targeted competitive antiviral drugs. However, their effectiveness has been compromised by...
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