Article
Sex chromosome-wide association analysis suggested male-specific risk genes for alcohol dependence.
Psychiatric genetics - 1 Dec 2013
Zuo Lingjun, Wang Kesheng, Zhang Xiangyang, Pan Xinghua, Wang Guilin, Krystal John H, Zhang Heping, Luo Xingguang
Abstract excerpt
BACKGROUND: Alcohol dependence is more common among men than among women. Potential explanations for this include the role of genes in sex chromosomes (X and Y). In the present study, we scanned the entire Y chromosome and its homologs on the X chromosome in men to identify male-specific risk genes for alcohol dependence. METHODS: Two thousand nine hundred and twenty-seven individuals in two independent cohorts...
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