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Article

Influence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients.

International journal of molecular medicine - 1 Dec 2011

Provenzani Alessio, Notarbartolo Monica, Labbozzetta Manuela, Poma Paola, Vizzini Giovanni, Salis Paola, Caccamo Chiara, Bertani Tullio, Palazzo Ugo, Polidori Piera, Gridelli Bruno, D'Alessandro Natale

Abstract excerpt

Tacrolimus is a substrate of cytochrome P4503A (CYP3A) enzymes as well as of the drug transporter ABCB1. We have investigated the possible influence of CYP3A5 and ABCB1 single nucleotide polymorphisms (SNPs) and other factors (e.g. albumin, hematocrit and steroids) on tacrolimus blood levels achieved in a population of Caucasian liver (n=51) and kidney (n=50) transplant recipients. At 1, 3 and 6 months after...

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Source

Identifiers

PMID: 21922127
DOI: 10.3892/ijmm.2011.794

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Influence of CYP3A5 and ABCB1 gene polymorphisms and other factors on tacrolimus dosing in Caucasian liver and kidney transplant patients.PMID 21922127Read ↗

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