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Article

The effect of CYP3A5 and ABCB1 single nucleotide polymorphisms on tacrolimus dose requirements in Caucasian liver transplant patients.

Annals of transplantation - 1 Jan 2000

Provenzani Alessio, Notarbartolo Monica, Labbozzetta Manuela, Poma Paola, Biondi Filippo, Sanguedolce Rosario, Vizzini Giovanni, Palazzo Ugo, Polidori Piera, Triolo Fabio, Gridelli Bruno, D'Alessandro Natale

Abstract excerpt

BACKGROUND: Tacrolimus is a substrate of cytochrome P-450 (CYP) 3A enzyme and of the drug transporter ABCB1. We have investigated the effects of possible relevant CYP3A5 and ABCB1 single nucleotide polymorphisms (SNPs) present in both donors and recipients on tacrolimus blood levels achieved in a population of 32 Caucasian liver transplant patients. MATERIAL/METHODS: At 1, 3 and 6 months after transplantation,...

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Identifiers

PMID: 19289993

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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