Article
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.
Human molecular genetics - 15 Dec 2013
Pooley Karen A, Bojesen Stig E, Weischer Maren, Nielsen Sune F, Thompson Deborah, Amin Al Olama Ali, Michailidou Kyriaki, Tyrer Jonathan P, Benlloch Sara, Brown Judith, Audley Tina, Luben Robert, Khaw K-T, Neal David E, Hamdy Freddie C, Donovan Jenny L, Kote-Jarai Zsofia, Baynes Caroline, Shah Mitul, Bolla Manjeet K, Wang Qin, Dennis Joe, Dicks Ed, Yang Rongxi, Rudolph Anja, Schildkraut Joellen, Chang-Claude Jenny, Burwinkel Barbara, Chenevix-Trench Georgia, Pharoah Paul D P, Berchuck Andrew, Eeles Rosalind A, Easton Douglas F, Dunning Alison M, Nordestgaard Børge G
Abstract excerpt
Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the "iCOGS" custom genotyping array. All ∼200 000 iCOGS variants were analysed with TL, and those displaying associations in healthy controls (n = 15 065) were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.